人类和果蝇近端启动子中的转录因子结合位点及其他特征。
Transcription factor binding sites and other features in human and Drosophila proximal promoters.
作者信息
Vinson Charles, Chatterjee Raghunath, Fitzgerald Peter
机构信息
Laboratory of Metabolism, NCI, NIH, Bethesda, MD, 20892, USA,
出版信息
Subcell Biochem. 2011;52:205-22. doi: 10.1007/978-90-481-9069-0_10.
Abstract
Eukaryotic promoters determine transcription start sites (TSSs), and are often enriched for transcription factor binding sites (TFBSs), which presumably play a major role in determining the location and activity of the TSS. In mammalian systems, proximal promoters are enriched for the CpG dinucleotide. The TFBSs that are enriched in proximal promoters (-200 bps to the TSS) are CCAAT, ETS, NRF1, SP1, E-Box, CRE, BoxA, and TATA. Only TATA occurs in a DNA strand dependent manner. In Drosophila, proximal promoters are AT rich and many putative TFBSs are enriched in proximal promoters. These sequences are different from those that occur in human promoters, except for TATA and E-Box, and many occur on a single strand of DNA giving directionality to the promoter. Thus, fundamental differences have arisen as promoters evolved in metazoans.
摘要
真核生物启动子决定转录起始位点（TSS），并且通常富含转录因子结合位点（TFBS），这些位点可能在决定TSS的位置和活性方面起主要作用。在哺乳动物系统中，近端启动子富含CpG二核苷酸。在近端启动子（TSS上游-200个碱基对）中富集的TFBS有CCAAT、ETS、NRF1、SP1、E-盒、CRE、盒A和TATA。只有TATA以依赖DNA链的方式出现。在果蝇中，近端启动子富含A/T，并且许多假定的TFBS在近端启动子中富集。除了TATA和E-盒外，这些序列与人类启动子中的序列不同，并且许多出现在单链DNA上，赋予启动子方向性。因此，随着后生动物启动子的进化，出现了根本差异。
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