神经元极性的维持。
Maintenance of neuronal polarity.
机构信息
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Dev Neurobiol. 2011 Jun;71(6):474-82. doi: 10.1002/dneu.20843.
Abstract
Neurons are highly polarized cells with distinct domains responsible for receiving, transmitting, and propagating electrical signals. Central to these functions is the axon initial segment (AIS), a short region of the axon adjacent to the cell body that is enriched in voltage-gated ion channels, cell adhesion molecules, and cytoskeletal scaffolding proteins. Traditionally, the function of the AIS has been limited to its role in action potential initiation and modulation. However, recent experiments indicate that it also plays essential roles in neuronal polarity. Here, we review how initial segments are assembled, and discuss proposed mechanisms for how the AIS contributes to maintenance of neuronal polarity.
摘要
神经元是具有高度极化特性的细胞，其不同的结构域分别负责接收、传递和传播电信号。这些功能的核心是轴突起始段（AIS），它是轴突紧邻细胞体的一小段区域，富含电压门控离子通道、细胞黏附分子和细胞骨架支架蛋白。传统上，AIS 的功能仅限于其在动作电位起始和调制中的作用。然而，最近的实验表明，它在神经元极性维持中也起着至关重要的作用。在这里，我们回顾了初始段的组装方式，并讨论了 AIS 如何有助于维持神经元极性的可能机制。
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本文引用的文献
1
Presynaptic activity regulates Na(+) channel distribution at the axon initial segment.突触前活动调节轴突起始段钠离子通道的分布。
Nature. 2010 Jun 24;465(7301):1075-8. doi: 10.1038/nature09087. Epub 2010 Jun 13.
2
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.活动依赖性的轴起始段重新定位精细调节神经元兴奋性。
Nature. 2010 Jun 24;465(7301):1070-4. doi: 10.1038/nature09160. Epub 2010 Jun 13.
3
ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.ADAM22，一种与 Kv1 通道相互作用的蛋白，将膜相关的鸟苷酸激酶募集到有髓轴突的连接部。
J Neurosci. 2010 Jan 20;30(3):1038-48. doi: 10.1523/JNEUROSCI.4661-09.2010.
4
CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila.接触蛋白相关蛋白2（CNTNAP2）和神经连接蛋白1（NRXN1）在常染色体隐性遗传性匹克-霍普金斯样智力障碍中发生突变，并决定果蝇中一种常见突触蛋白的水平。
Am J Hum Genet. 2009 Nov;85(5):655-66. doi: 10.1016/j.ajhg.2009.10.004. Epub 2009 Nov 5.
5
Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury.轴突起始段细胞骨架的破坏是神经元损伤的一种新机制。
J Neurosci. 2009 Oct 21;29(42):13242-54. doi: 10.1523/JNEUROSCI.3376-09.2009.
6
AnkyrinG is required to maintain axo-dendritic polarity in vivo.锚蛋白G是在体内维持轴突-树突极性所必需的。
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17564-9. doi: 10.1073/pnas.0909267106. Epub 2009 Sep 24.
7
Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation.Na(v)1.6和Na(v)1.2在动作电位起始和逆向传播中的不同作用。
Nat Neurosci. 2009 Aug;12(8):996-1002. doi: 10.1038/nn.2359. Epub 2009 Jul 26.
8
Establishment of axon-dendrite polarity in developing neurons.发育中神经元轴突 - 树突极性的建立。
Annu Rev Neurosci. 2009;32:347-81. doi: 10.1146/annurev.neuro.31.060407.125536.
9
A selective filter for cytoplasmic transport at the axon initial segment.轴突起始段细胞质运输的选择性过滤器。
Cell. 2009 Mar 20;136(6):1148-60. doi: 10.1016/j.cell.2009.01.016. Epub 2009 Mar 5.
10
Axonal sodium-channel bands shape the response to electric stimulation in retinal ganglion cells.轴突钠通道带塑造视网膜神经节细胞对电刺激的反应。
J Neurophysiol. 2009 Apr;101(4):1972-87. doi: 10.1152/jn.91081.2008. Epub 2009 Feb 4.
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