Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany.
Acta Paediatr. 2011 Dec;100(12):e267-74. doi: 10.1111/j.1651-2227.2011.02348.x. Epub 2011 Jun 11.
Faecal incontinence (FI) is a common disorder involving both the enteric (ENS) and central nervous systems (CNS). The aim of the study is to analyze neurophysiologically the central processing of emotions in children with FI, healthy controls and children with Attention-deficit hyperactivity disorder (ADHD).
Fourteen children with FI and constipation, nine with non-retentive FI, 15 controls and 13 children with ADHD were examined. The methods included a physical exam, sonography, Child Behavior Checklist, a psychiatric interview and intelligence test. Acoustic evoked potentials were recorded according to standardized methodology. For the event-related potentials, 80 neutral, 40 positive and 40 negative pictures from the International Affective Picture System (IAPS), and 40 pictures depicting faeces were presented.
Children with FI had significantly more intense responses for most stimuli over the frontal, central and parietal regions compared to controls. Stool pictures did not evoke stronger responses than other stimuli. Children with constipation elicited stronger responses. Children with ADHD did not differ from controls. Acoustic evoked potentials were comparable in all groups.
Children with FI have increased responses in the processing of emotions. These can be interpreted as a neurobiological vulnerability, possibly due to the association of the ENS and CNS.
粪便失禁（FI）是一种涉及肠内（ENS）和中枢神经系统（CNS）的常见疾病。本研究旨在分析有 FI、健康对照和注意力缺陷多动障碍（ADHD）儿童的情绪的中枢处理的神经生理学。
检查了 14 名有 FI 和便秘的儿童、9 名非保留性 FI 儿童、15 名对照和 13 名 ADHD 儿童。方法包括体检、超声检查、儿童行为检查表、精神病学访谈和智力测试。根据标准化方法记录声诱发电位。对于事件相关电位，从国际情感图片系统（IAPS）呈现 80 张中性、40 张正性和 40 张负性图片，以及 40 张粪便图片。
与对照组相比，FI 儿童在前额、中央和顶叶区域对大多数刺激的反应明显更强烈。粪便图片并没有比其他刺激引发更强的反应。便秘儿童的反应更强。ADHD 儿童与对照组无差异。各组的声诱发电位相似。
FI 儿童在情绪处理中反应增强。这些可以解释为神经生物学易感性，可能是由于 ENS 和 CNS 的关联。
