Waeber C, Hoyer D, Palacios J M
Preclinical Research, Sandoz Ltd., Basel, Switzerland.
Eur J Pharmacol. 1990 Feb 6;176(2):233-6. doi: 10.1016/0014-2999(90)90534-d.
The distribution of binding sites for 125I-labelled endothelins (ET-1, ET-2, ET-3) and sarafotoxin-6b (SRTX-6b) was visualized in human kidneys using autoradiography. The glomeruli, the internal medulla and the renal blood vessels presented the highest levels of labelling, while the outer medulla exhibited intermediate and the cortex lower densities of sites. The relative enrichment of binding sites in different renal areas was similar for each peptide, suggesting the existence of a homogeneous population of endothelin/sarafotoxin receptors.
采用放射自显影法，在人肾中观察了¹²⁵I标记的内皮素（ET-1、ET-2、ET-3）和尾加压素-6b（SRTX-6b）结合位点的分布。肾小球、肾内髓和肾血管呈现出最高的标记水平，而外髓的位点密度中等，皮质的位点密度较低。每种肽在不同肾区结合位点的相对富集情况相似，提示存在内皮素/尾加压素受体的同质群体。
