Department of Neurology, F.M. Kirby Neurobiology Center, Children's Hospital, Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.
Curr Opin Neurobiol. 2011 Apr;21(2):228-37. doi: 10.1016/j.conb.2011.02.007.
The formation and refinement of synaptic circuits are areas of research that have fascinated neurobiologists for decades. A recurrent theme seen at many CNS synapses is that neuronal connections are at first imprecise, but refine and can be rearranged with time or with experience. Today, with the advent of new technologies to map and monitor neuronal circuits, it is worthwhile to revisit a powerful experimental model for examining the development and plasticity of synaptic circuits--the retinogeniculate synapse.
突触回路的形成和精细化是神经生物学家几十年来着迷的研究领域。在许多中枢神经系统突触中可以看到一个反复出现的主题，即神经元连接最初是不精确的，但随着时间或经验的推移会进行精细调整和重新排列。如今，随着新技术的出现来绘制和监测神经元回路，重新审视用于研究突触回路发育和可塑性的强大实验模型——视网膜-视顶盖突触是很有价值的。
