Department of Abdominal Surgery, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Exp Biol Med (Maywood). 2011 Jun 1;236(6):723-8. doi: 10.1258/ebm.2011.010295. Epub 2011 May 9.
Glutathione S-transferase M1 (GSTM1) might be involved in inactivation of procarcinogens that contribute to the genesis and progression of cancers. GSTM1 null status has been extensively studied as a risk factor in bladder cancer susceptibility. The aim of this study is to evaluate the role of GSTM1 null genotype in bladder cancer risk. All available studies were considered in this meta-analysis, including 7301 cases and 9405 controls from 33 studies. Significantly increased risk was detected between GSTM1 deletion and bladder cancer susceptibility in all subjects (odds ratio [OR] = 1.409 [1.267-1.568], P < 0.001). The same patterns were observed in Caucasians (OR = 1.434 [1.212-1.697], P < 0.001) and Asians (OR = 1.485 [1.295-1.704], P < 0.001). When stratified with study design, a positive association was also found in hospital-based studies (OR = 1.552 [1.382-1.744], P < 0.001), but no association in population-based ones (OR = 1.088 [0.970-1.221], P = 0.151). In summary, our meta-analysis suggested that GSTM1 null status is associated with a high increase in the risk of bladder cancer, and further studies based on population design are necessary to confirm our conclusion.
谷胱甘肽 S-转移酶 M1（GSTM1）可能参与前致癌物的失活，而前致癌物有助于癌症的发生和发展。GSTM1 缺失状态已被广泛研究作为膀胱癌易感性的危险因素。本研究旨在评估 GSTM1 缺失基因型在膀胱癌风险中的作用。本荟萃分析考虑了所有可用的研究，包括 33 项研究中的 7301 例病例和 9405 例对照。在所有受试者中，GSTM1 缺失与膀胱癌易感性之间存在显著的相关性（比值比 [OR] = 1.409 [1.267-1.568]，P < 0.001）。在白种人和亚洲人中也观察到了相同的模式（OR = 1.434 [1.212-1.697]，P < 0.001；OR = 1.485 [1.295-1.704]，P < 0.001）。按研究设计分层时，在基于医院的研究中也发现了阳性关联（OR = 1.552 [1.382-1.744]，P < 0.001），但在基于人群的研究中没有关联（OR = 1.088 [0.970-1.221]，P = 0.151）。总之，我们的荟萃分析表明，GSTM1 缺失状态与膀胱癌风险的显著增加有关，需要基于人群设计的进一步研究来证实我们的结论。
