Department of Urology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China.
Mol Biol Rep. 2011 Apr;38(4):2491-7. doi: 10.1007/s11033-010-0386-6. Epub 2010 Nov 17.
Studies investigating the association between glutathione S-transferase M1 (GSTM1) polymorphism and bladder cancer risk report conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. We performed a systematic search of the National Library of Medline and Embase databases. This meta-analysis included 26 case-control studies, which included 5029 bladder cancer cases and 6680 controls. The combined results based on all studies showed that the GSTM1 null genotype was associated with an increased risk of bladder cancer (OR=1.46, 95% confidence interval [CI]=1.35, 1.57). When stratifying for race, results were similar among Asians (OR=1.60, 95% CI=1.27, 2.01) and Caucasians (OR=1.44, 95% CI=1.33, 1.57) except Africans (OR=1.25, 95% CI=0.76, 2.06). When stratifying by the smoking, stage, grade, and histological type of bladder cancer, we found no statistical association. Our meta-analysis suggests that the GSTM1 null genotype is associated with a modest increase in the risk of bladder cancer.
研究调查谷胱甘肽 S-转移酶 M1 (GSTM1) 多态性与膀胱癌风险之间的关联，报告结果相互矛盾。本研究的目的是定量总结这种关系的证据。我们对国家医学图书馆 Medline 和 Embase 数据库进行了系统搜索。这项荟萃分析包括 26 项病例对照研究，包括 5029 例膀胱癌病例和 6680 例对照。基于所有研究的综合结果表明，GSTM1 缺失基因型与膀胱癌风险增加相关（OR=1.46，95%置信区间 [CI]=1.35，1.57）。按种族分层时，亚洲人（OR=1.60，95% CI=1.27，2.01）和高加索人（OR=1.44，95% CI=1.33，1.57）的结果相似，但非洲人除外（OR=1.25，95% CI=0.76，2.06）。按膀胱癌的吸烟、分期、分级和组织学类型分层时，我们没有发现统计学关联。我们的荟萃分析表明，GSTM1 缺失基因型与膀胱癌风险的适度增加相关。
