Rolfes N, Lümmen G
Abteilung für Urologie, Kinderurologie und Uro-Onkologie, St. Josef-Hospital, Hospitalstraße 45, 53840 Troisdorf, Deutschland.
Urologe A. 2011 Jul;50(7):810-2. doi: 10.1007/s00120-011-2576-9.
Febrile neutropenia is a severe complication of systemic chemotherapy and has a negative effect on morbidity, mortality and prognosis. It is usually caused by bacterial infection. Therefore patients at high risk should prophylactically be given GCSF and a fluoroquinolone. In most cases neutropenic fever requires hospitalization and immediate empiric antibiotic therapy following baseline diagnostics. If there is no improvement after 72-96 h, therapy should be modified and further tests initiated. In these cases fungal or viral infection should be considered.
发热性中性粒细胞减少是全身化疗的一种严重并发症,对发病率、死亡率和预后有负面影响。它通常由细菌感染引起。因此,高危患者应预防性给予粒细胞集落刺激因子(GCSF)和氟喹诺酮类药物。在大多数情况下,中性粒细胞减少性发热需要住院治疗,并在进行基线诊断后立即给予经验性抗生素治疗。如果72 - 96小时后没有改善,应调整治疗方案并开始进一步检查。在这些情况下,应考虑真菌或病毒感染。