Plastic Surgery Unit, University of Bari Medical School, Policlinico, Bari, Italy.
Clin Exp Med. 2012 Mar;12(1):55-60. doi: 10.1007/s10238-011-0136-7. Epub 2011 May 11.
Venous leg ulcer is a pathological condition afflicting prevalently elderly patients, which has been found to have a major impact on individuals' health and social aspects of quality of life. Actually, the best practice treatment is recommended to include wound dressing and multilayer compression therapy. In this study, we have tested the effectiveness and safety of Vulnamin(®), a novel dressing in the form of a metal cellulose gel containing the amino acids glycine, L: -lysine, L: -proline, L: -leucine, and hyaluronic acid, and elastic compressive bandages in the treatment of chronic venous ulcers of the lower limbs. The study has been conducted in two groups of patients, one treated with Vulnamin(®) plus Ca-alginate (ulcer duration = 25.4 ± 6.2 weeks; mean baseline ulcer area = 13.9 ± 4.5 cm(2)) and a control group treated with Ca-alginate alone (ulcer duration = 23.4 ± 4.2 weeks; mean baseline ulcer area = 15.1 ± 4.7 cm(2)). Results have shown that after 70 days of treatment patients significantly ameliorate their pathological condition if they are treated with Vulnamin(®), as compared with patients treated with Ca-alginate alone. In fact, at the end of the treatment, complete healing closure was 61% in the group treated with Vulnamin(®) and, respectively, 27% in the control group. Moreover, ulcer areas showed a significant reduction in patients treated with Vulnamin(®) (mean ulcer area = 3.04 ± 0.8 cm(2)), as compared with controls (mean ulcer area = 10.96 ± 3.8 cm(2)). Overall, the results of this study indicate that Vulnamin(®) together with elastocompression is safe and more effective than standard dressing together with elastocompression in inducing a faster healing in chronic venous ulcers of the lower limb.
静脉性腿部溃疡是一种主要影响老年人健康和生活质量社会方面的病理状况。实际上，推荐的最佳实践治疗包括伤口敷料和多层压缩治疗。在这项研究中，我们测试了一种新型敷料 Vulnamin（®）的有效性和安全性，它是一种金属纤维素凝胶形式的敷料，含有氨基酸甘氨酸、L-赖氨酸、L-脯氨酸、L-亮氨酸和透明质酸，以及弹性压缩绷带，用于治疗下肢慢性静脉性溃疡。这项研究在两组患者中进行，一组用 Vulnamin（®）加钙藻酸盐治疗（溃疡持续时间=25.4±6.2 周；平均基线溃疡面积=13.9±4.5cm²），对照组用单独的钙藻酸盐治疗（溃疡持续时间=23.4±4.2 周；平均基线溃疡面积=15.1±4.7cm²）。结果表明，在治疗 70 天后，与单独使用钙藻酸盐治疗的患者相比，用 Vulnamin（®）治疗的患者病情明显改善。事实上，在治疗结束时，用 Vulnamin（®）治疗的患者中有 61%完全愈合，而对照组则为 27%。此外，用 Vulnamin（®）治疗的患者的溃疡面积明显减少（平均溃疡面积=3.04±0.8cm²），而对照组的溃疡面积则明显减少（平均溃疡面积=10.96±3.8cm²）。总的来说，这项研究的结果表明，Vulnamin（®）联合弹性压缩比标准敷料联合弹性压缩更安全、更有效，能更快地治愈下肢慢性静脉性溃疡。
