Vercruysse K P, Prestwich G D
Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City 84112-5820, USA.
Crit Rev Ther Drug Carrier Syst. 1998;15(5):513-55.
Hyaluronan (HA), an abundant nonsulfated glycosaminoglycan component of synovial fluid and the extracellular matrix, is an attractive building block for new biocompatible and biodegradable polymers that have applications in drug delivery, tissue engineering, and viscosupplementation. This review consists of three subtopics: (i) chemical modification of HA; (ii) physicochemical and biochemical characterization of HA derivatives; and (iii) in vitro and in vivo bioevaluation studies. Important new products have already reached the marketplace, and the approval and introduction of a variety of new medical applications of HA-based biomaterials can be anticipated in the next decade.
透明质酸（HA）是滑液和细胞外基质中一种丰富的非硫酸化糖胺聚糖成分，是新型生物相容性和可生物降解聚合物的理想构建单元，这些聚合物可应用于药物递送、组织工程和粘性补充疗法。本综述包括三个子主题：（i）HA的化学修饰；（ii）HA衍生物的物理化学和生化特性；（iii）体外和体内生物评价研究。重要的新产品已经上市，预计在未来十年内，基于HA的生物材料的各种新医疗应用将获得批准并推出。
