Mikheeva O M
Eksp Klin Gastroenterol. 2011(2):121-4.
Liver metabolism aims to change the biological activity of drugs to make them water-soluble to be excreted with bile and urine. The degree of metabolism depends on fermentative capacity for each drag (P450 fermentative system is localized in microsomal fraction of hepatocyte). Metabolism ability also changes under the influence of other substances. Liver diseases lead up to decrease of drug clirens and to increase the semi-excretion time because of reduction of liver metabolism. Therefore the drags usually undergoing intensive liver metabolism necessitate a high risk of overdose when liver diseases present. On the other hand no risk of overdose exist when drags with low liver metabolism are used.
肝脏代谢旨在改变药物的生物活性，使其具有水溶性，以便通过胆汁和尿液排出。代谢程度取决于每种药物的发酵能力（P450发酵系统位于肝细胞的微粒体部分）。代谢能力也会在其他物质的影响下发生变化。肝脏疾病会导致药物清除率降低，由于肝脏代谢减少，药物半衰期延长。因此，通常在肝脏疾病存在时，那些通常经历强烈肝脏代谢的药物有很高的过量用药风险。另一方面，使用肝脏代谢低的药物则不存在过量用药风险。
