Fang Shangping, Li Pengfei, Zhu Chenxu, Han Xiaoxiao, Bao Pengju, Guo Wenjun
School of Anaesthesia, Wannan Medical College Wuhu, Anhui, China.
Department of Anesthesiology, Yi Jishan Hospital Affiliated to Wannan Medical College Wuhu, Anhui, China.
Int J Clin Exp Pathol. 2020 Nov 1;13(11):2720-2726. eCollection 2020.
Ulinastatin (UTI) is a trypsin inhibitor observed in urine. UTI can treat some diseases by inhibiting the broad-spectrum hydrolysis activity of various enzymes and other pharmacological effects. UTI can widely treat pancreatitis, systemic multiple organ dysfunction syndrome, circulatory failure, and toxic shock clinically. The liver is a major metabolic organ of the human body. Various biological metabolic reactions require the liver's participation. When various physical and chemical factors drive the body, it will damage the liver to varying degrees. As a clinically effective drug, UTI is also known to treat some liver diseases. This article mainly describes UTI's research progress in treating septic liver injury, hepatitis, liver fibrosis, autoimmune liver disease with liver failure, and liver ischemia-reperfusion injury.
乌司他丁（UTI）是一种在尿液中发现的胰蛋白酶抑制剂。UTI可通过抑制多种酶的广谱水解活性及其他药理作用来治疗某些疾病。UTI在临床上可广泛治疗胰腺炎、全身性多器官功能障碍综合征、循环衰竭及中毒性休克。肝脏是人体的主要代谢器官。各种生物代谢反应都需要肝脏参与。当各种理化因素作用于机体时，会不同程度地损害肝脏。作为一种临床有效的药物，UTI也被认为可治疗某些肝脏疾病。本文主要介绍UTI在治疗脓毒症肝损伤、肝炎、肝纤维化、自身免疫性肝病伴肝衰竭及肝缺血-再灌注损伤方面的研究进展。
