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剪切应力在离散性主动脉瓣下狭窄发病机制中的作用：对手术治疗的启示。

The role of shear stress in the pathogenesis of discrete subaortic stenosis: implications for surgical treatment.

作者信息

Silbiger Jeffrey J

机构信息

Mount Sinai School of Medicine, New York City, NY, USA.

出版信息

J Heart Valve Dis. 2011 Mar;20(2):123-8.

PMID:21560809
Abstract

Discrete subaortic stenosis (DSS) is characterized by the presence of an obstructing membrane in the left ventricular outflow tract (LVOT). Evidence suggests that the formation of DSS represents a fibroproliferative reaction of the endocardium occurring in response to alterations in shear stress caused by geometric abnormalities within the LVOT. The aim of this review is to discuss the role of altered LVOT shear stress in the pathogenesis of DSS, and its implications in surgical decision making.

摘要

离散性主动脉瓣下狭窄（DSS）的特征是左心室流出道（LVOT）存在阻塞性隔膜。有证据表明，DSS的形成代表了心内膜的纤维增生反应，这种反应是由LVOT内几何形态异常引起的剪切应力改变所触发的。本综述的目的是探讨LVOT剪切应力改变在DSS发病机制中的作用及其在手术决策中的意义。

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