Carpiniello V L, Schoenberg M, Malloy T R
J Urol. 1990 Apr;143(4):726-8. doi: 10.1016/s0022-5347(17)40073-5.
We evaluated 162 high risk male patients for the presence of subclinical anogenital human papillomavirus infection with magnified penile surface scanning. Infected patients were treated as outpatients with the carbon dioxide laser under local anesthesia. Of the patients 43 were followed for a mean of 8.7 months or 2.1 treatments after the initial treatment (range 3 to 30 months). A subset of 10 patients was followed for more than 20 months or 6.2 treatments. To date a 51% recurrence rate has been observed in the over-all population and a 50% recurrence rate was noted in the 20-month followup population. In a separate arm of this study a small number of patients (15) with deoxyribonucleic acid typed subclinical intraurethral disease plus subclinical skin lesions were treated with topical carbon dioxide laser therapy for the penile lesions and adjuvant intraurethral 5% 5-fluorouracil. Mean followup in the group was approximately 4 months. The addition of intraurethral therapy in this positive human papillomavirus reservoir group had no significant effect on the high rate of human papillomavirus recurrence.
我们通过放大阴茎表面扫描对162例高危男性患者进行了亚临床肛门生殖器人乳头瘤病毒感染情况的评估。感染患者在局部麻醉下接受二氧化碳激光门诊治疗。其中43例患者在初始治疗后平均随访8.7个月或接受2.1次治疗（范围3至30个月）。10例患者的亚组随访时间超过20个月或接受6.2次治疗。迄今为止，在总体人群中观察到的复发率为51%，在20个月随访人群中的复发率为50%。在本研究的另一个分支中，对少数（15例）经脱氧核糖核酸分型的亚临床尿道内疾病合并亚临床皮肤病变的患者，阴茎病变采用局部二氧化碳激光治疗，尿道内辅助使用5% 5-氟尿嘧啶。该组的平均随访时间约为4个月。在这个阳性人乳头瘤病毒储存库组中添加尿道内治疗对人乳头瘤病毒的高复发率没有显著影响。
