Carpiniello V L, Malloy T R, Sedlacek T V, Zderic S A
Department of Urology, Pennsylvania Hospital, Philadelphia.
J Urol. 1988 Jul;140(1):53-4. doi: 10.1016/s0022-5347(17)41484-4.
Previously we demonstrated a 68 per cent recurrence rate for subclinical penile human papillomavirus infections found by magnified penile surface scanning and treated with the carbon dioxide laser. In this report it is shown that the addition of a regimen of adjuvant topical 5-fluorouracil does not lower the recurrence rate. This knowledge combined with the evidence for a subclinical urethral reservoir of human papillomavirus implies that any strictly topical therapy will fail at 4 months of followup and that improved systemic therapy may be needed.
此前我们通过阴茎表面放大扫描发现亚临床阴茎人乳头瘤病毒感染，并用二氧化碳激光治疗，结果显示复发率为68%。本报告表明，添加辅助性局部5-氟尿嘧啶治疗方案并不能降低复发率。这一认识，再结合人乳头瘤病毒亚临床尿道储存库的证据，意味着任何严格的局部治疗在随访4个月时都会失败，可能需要改进全身治疗。
