Department of Biological Technology, Jiangxi Institute of Education, Nanchang, PR China.
Hereditas. 2011 Apr;148(2):63-9. doi: 10.1111/j.1601-5223.2010.02210.x. Epub 2011 Apr 15.
The association between recombination rate and diversity, but not divergence is considered to be driven mainly by natural selection: fixation of positively selected variants and associated hitchhiking effects and/or background selection eliminating deleterious alleles. In the present study, we investigated the relationship between recombination rate, SNP diversity and interspecies divergence for 29 loci in chickens. We found that recombination rate is positively correlated with nucleotide diversity but is not correlated with interspecies divergence. It appears that variation in recombination rate explains over 30% of the variation in levels of diversity among 29 loci. Our data suggested that natural selection is a main factor in shaping SNP diversity in chickens. Since SNP diversity is significantly lower at Z-linked than at autosomal loci, we argued that genetic hitchhiking might be more important than background selection in producing the observed correlation.
重组率与多样性之间的关联，而不是分歧，被认为主要是由自然选择驱动的：正选择变体的固定以及相关的连锁不平衡效应和/或背景选择消除有害等位基因。在本研究中，我们研究了鸡的 29 个基因座的重组率、SNP 多样性和种间分歧之间的关系。我们发现，重组率与核苷酸多样性呈正相关，但与种间分歧无关。看来，重组率的变化解释了 29 个基因座之间多样性水平差异的 30%以上。我们的数据表明，自然选择是塑造鸡中 SNP 多样性的主要因素。由于 Z 连锁基因座上的 SNP 多样性明显低于常染色体基因座，我们认为遗传连锁不平衡比背景选择更重要，这导致了观察到的相关性。
