Department of Anesthesiology, Changhua Christian Hospital, Changhua County 500, Taiwan.
Phytomedicine. 2011 Oct 15;18(13):1126-9. doi: 10.1016/j.phymed.2011.03.007. Epub 2011 May 10.
Honokiol, an active agent extracted from magnolia bark, has been reported that induces anxiolytic action in a mouse elevated plus-maze test. However, the mechanism of anxiolytic action induced by honokiol remains unclear. This study was to investigate the change in two forms of glutamic acid decarboxylase (GABA synthesized enzymes) GAD(65) and GAD(67) in the cortex and hippocampus areas while the anxiolytic actions induced by chronic administration of honokiol in mice. Mice treated with 7 daily injection of honokiol (1mg/kg, p.o.) caused anxiolytic action which was similar to that was induced by 7 daily injection of diazepam (2mg/kg, p.o.) in the elevated plus-maze test. In addition, the activity of hippocampal GAD(65) of honokiol treated mice was significantly increased than that of the vehicle or diazepam treated groups. These data suggest that honokiol causes diazepam-like anxiolytic action, which may be mediated by altering the synthesis of GABA in the brain of mice.
厚朴酚是从木兰树皮中提取的一种活性成分，据报道它在小鼠高架十字迷宫试验中具有抗焦虑作用。然而，厚朴酚诱导抗焦虑作用的机制尚不清楚。本研究旨在探讨慢性给予厚朴酚后，小鼠皮质和海马区两种谷氨酸脱羧酶（GABA 合成酶）GAD（65）和 GAD（67）的变化，以及其抗焦虑作用。连续 7 天给予厚朴酚（1mg/kg，po）的小鼠在高架十字迷宫试验中表现出与连续 7 天给予地西泮（2mg/kg，po）相似的抗焦虑作用。此外，厚朴酚处理小鼠的海马 GAD（65）活性明显高于载体或地西泮处理组。这些数据表明，厚朴酚引起类似地西泮的抗焦虑作用，这可能是通过改变小鼠大脑中 GABA 的合成来介导的。
