鉴定厚朴酚与和厚朴酚为汉方药柴朴汤提取物中的抗焦虑剂。
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine.
作者信息
Maruyama Y, Kuribara H, Morita M, Yuzurihara M, Weintraub S T
机构信息
Department of Neuropsychopharmacology, Gunma University School of Medicine, Japan.
出版信息
J Nat Prod. 1998 Jan;61(1):135-8. doi: 10.1021/np9702446.
PMID:9461663
Abstract
The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2-propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.
摘要
柴朴汤（一种东方草药）中的主要抗焦虑活性成分已被分离并鉴定为厚朴酚（5,5'-二-2-丙烯基-1,1'-联苯-2,2'-二醇）和和厚朴酚（3',5-二-2-丙烯基-1,1'-联苯-2,4'-二醇）。通过高架十字迷宫试验评估表明，当给小鼠口服给药7天时，和厚朴酚的效力比柴朴汤至少强5000倍。
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