Unit of Human Pathology, Department of Medicine, Surgery and Dentistry, San Paolo Hospital Medical School, University of Milano, Italy.
J Clin Pathol. 2011 Jul;64(7):605-9. doi: 10.1136/jcp.2010.088765. Epub 2011 May 10.
Muscularised basal plate arteries (MA) or chorioamnionitis (CA) are often present in placental abruption. The aim of this study was to evaluate the placental expression of COX 1 and COX 2 in cases of placental abruption with MA or CA hypothesising that an imbalance in COX placental expression might be implicated in its pathogenesis.
COX 1 and COX 2 placental immunostaining was analysed in 16 placentas with abruption (nine with MA, seven with CA), in 26 normal placentas and in 10 gestational age-matched MA or CA cases without abruption.
COX 1 and COX 2 protein expression was observed in all cases, both in placental abruption and in normal placentas. No differences in distribution of immunoreactivity were observed either between cases and controls or between MA and CA. The mean COX 1 ratio between COX-positive cells and all stromal cells was significantly lower in placental abruption with MA (0.14±0.05) when compared with cases with CA (0.35±0.06) and normal placenta (0.23±0.02; p<0.001). The mean COX 2 ratio was lower in placental abruption with MA than in normal placenta (0.09±0.06 vs 0.18±0.05: p<0.001). In contrast, no difference in COX 1 and COX 2 ratio was observed between MA cases with or without abruption and between CA cases with or without abruption.
It is hypothesised that an imbalance of normal COX level may be present in cases with MA and CA but it is not related to placental abruption.
肌层化基底胎盘动脉（MA）或绒毛膜羊膜炎（CA）在胎盘早剥中常存在。本研究旨在评估胎盘早剥伴 MA 或 CA 时 COX1 和 COX2 的胎盘表达，假设 COX 胎盘表达失衡可能与其发病机制有关。
分析了 16 例胎盘早剥（9 例 MA，7 例 CA）、26 例正常胎盘和 10 例与 MA 或 CA 无胎盘早剥的胎龄匹配 MA 或 CA 病例的 COX1 和 COX2 胎盘免疫染色。
在所有病例中，包括胎盘早剥和正常胎盘，均观察到 COX1 和 COX2 蛋白表达。无论是病例与对照组之间，还是 MA 与 CA 之间，免疫反应性的分布均无差异。与 CA 组（0.35±0.06）和正常胎盘组（0.23±0.02；p<0.001）相比，MA 组（0.14±0.05）COX1 阳性细胞与所有基质细胞的阳性细胞比值明显较低。MA 组胎盘早剥的 COX2 比值低于正常胎盘（0.09±0.06 vs 0.18±0.05：p<0.001）。相比之下，MA 伴或不伴胎盘早剥的病例以及 CA 伴或不伴胎盘早剥的病例之间 COX1 和 COX2 比值无差异。
假设 MA 和 CA 病例中存在正常 COX 水平失衡，但与胎盘早剥无关。
