破伤风毒素会导致大鼠海马体中的神经元损失以及GABAA结合位点减少，但不会导致GABAB结合位点减少。
Tetanus toxin produces neuronal loss and a reduction in GABAA but not GABAB binding sites in rat hippocampus.
作者信息
Bagetta G, Knott C, Nisticó G, Bowery N G
机构信息
Department of Pharmacology, School of Pharmacy, London, U.K.
出版信息
Neurosci Lett. 1990 Feb 5;109(1-2):7-12. doi: 10.1016/0304-3940(90)90529-i.
PMID:2156194
Abstract
The neuropathological effects of tetanus toxin, microinjected in the rat CA1 hippocampal area, were studied by using a microscopical and autoradiographical approach. Tetanus toxin produced a dose- and time-dependent neuronal loss in the CA1 area accompanied by a reduction in the binding of gamma-[3H]aminobutyric acid ([3H]GABA) to GABAA but not GABAB sites in the pyramidal cell layer.
摘要
通过显微镜和放射自显影方法，研究了微量注射到大鼠CA1海马区的破伤风毒素的神经病理学效应。破伤风毒素在CA1区产生剂量和时间依赖性的神经元损失，同时锥体细胞层中γ-[3H]氨基丁酸（[3H]GABA）与GABAA而非GABAB位点的结合减少。
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