Department of Ophthalmology, National University Health System, Singapore.
J Glaucoma. 2012 Jun-Jul;21(5):313-7. doi: 10.1097/IJG.0b013e31820e2d23.
To quantify changes in bleb morphology after laser suture lysis (LSL) using anterior segment optical coherence tomography (AS-OCT).
This was a prospective observational case series of patients who underwent trabeculectomy surgery with mitomycin-C and required subsequent LSL. Subjects were assessed before and immediately after LSL, and at 3 months after LSL. At each visit, a standardized cross-sectional AS-OCT image of the bleb was obtained, from which a masked observer measured bleb height (hB), cavity height (hC), wall cross sectional area (AW), cavity cross sectional area (AC), and bleb cross sectional area (AB) using custom software.
Twenty-five subjects (25 eyes) were examined. LSL was performed at a mean of 21.5±16.3 days after trabeculectomy. Immediately after LSL, there was a significant increase in mean hB (P=0.026) and mean hC (P=0.45) from pre-LSL. At 3 months after LSL, there was a significant increase in mean hB (P=0.003), mean AC (P=0.047), and mean AB (P=0.006) as compared with before LSL. Increase in hB and hC immediately after LSL was predictive of outcome at month 3.
AS-OCT was able to quantify changes in bleb morphology after LSL, some of which were predictive of eventual outcome.
使用眼前节光学相干断层扫描（AS-OCT）定量分析激光缝合松解（LSL）后滤过泡形态的变化。
这是一项前瞻性观察性病例系列研究，纳入了接受丝裂霉素 C 小梁切除术且需要后续行 LSL 的患者。受试者在 LSL 前、LSL 后即刻以及 LSL 后 3 个月接受评估。每次就诊时，均使用标准化的 AS-OCT 对滤过泡进行横断面成像，然后由一名盲法观察者使用定制软件测量滤过泡高度（hB）、腔高度（hC）、壁截面积（AW）、腔截面积（AC）和滤过泡截面积（AB）。
共检查了 25 名患者（25 只眼）。LSL 在小梁切除术后平均 21.5±16.3 天进行。与 LSL 前相比，LSL 后即刻 hB 和 hC 的平均值均显著增加（P=0.026 和 P=0.45）。LSL 后 3 个月，hB、AC 和 AB 的平均值与 LSL 前相比均显著增加（P=0.003、P=0.047 和 P=0.006）。LSL 后即刻 hB 和 hC 的增加与 3 个月时的结局相关。
AS-OCT 能够定量分析 LSL 后滤过泡形态的变化，其中一些变化与最终结局相关。
