Delft University of Technology, Dept. of Chemical Engineering, Product and Process Engineering, Julianalaan 136, 2628 BL Delft, The Netherlands.
Lab Chip. 2011 Jun 21;11(12):2035-8. doi: 10.1039/c0lc00550a. Epub 2011 May 11.
We demonstrate a rapid fabrication procedure for solvent-resistant microfluidic devices based on the perfluoropolyether (PFPE) SIFEL. We carefully modified the poly-dimethylsiloxane (PDMS) micromolding procedure, such that it can still be executed using the standard facilities for PDMS devices. Most importantly, devices with a thin SIFEL layer for the patterned channels and a PDMS support layer on top offered the best of two worlds in terms of chemical and mechanical stability during fabrication and use. Tests revealed that these devices overcome two important drawbacks of PDMS devices: (i) incompatibility with almost all non-aqueous solvents, and (ii) leaching of oligomer into solution. The potential of our device is shown by performing a relevant organic synthesis reaction with aggressive reactants and solvents. PFPE-PDMS devices will greatly expand the application window of micromolded devices.
我们展示了一种基于全氟聚醚（PFPE）SIFEL 的耐溶剂微流控器件的快速制造方法。我们仔细修改了聚二甲基硅氧烷（PDMS）微模塑工艺，以便仍然可以使用 PDMS 器件的标准设备来执行。最重要的是，具有薄的 SIFEL 层的图案化通道和 PDMS 支撑层的器件在制造和使用过程中在化学和机械稳定性方面提供了两全其美。测试表明，这些器件克服了 PDMS 器件的两个重要缺点：（i）与几乎所有非水溶剂不兼容，以及（ii）低聚物浸出到溶液中。通过使用刺激性反应物和溶剂进行相关的有机合成反应，展示了我们的设备的潜力。PFPE-PDMS 器件将极大地扩展微模塑器件的应用范围。
