Letterkenny General Hospital, Letterkenny, Co. Donegal, Ireland.
Ir J Med Sci. 2012 Jun;181(2):263-4. doi: 10.1007/s11845-011-0717-1. Epub 2011 May 12.
Avascular necrosis (AVN) is a well-recognized complication of patients on high-dose steroids for a long time. Exogenous hypercortisolism is a well known cause of AVN and a number of cases have been reported. Cushing's syndrome describes hypercortisolism of any cause endogenous or exogenous. A variety of traumatic and non-traumatic factors contribute to the aetiology of AVN although exogenous glucocorticoids administration and alcoholism are among the most common non-traumatic causes. AVN secondary to endogenous hypercortisolism is rare and very few case reports are available describing this complication. No literature is available on AVN presenting post-adrenal surgery. Here we present a young woman who presented with avascular necrosis of both hips 1 year after adrenalectomy for Cushing's syndrome.
骨坏死（AVN）是长期大剂量使用类固醇的患者的一种公认并发症。外源性皮质醇增多症是 AVN 的已知原因，已有许多病例报道。库欣综合征描述了任何原因的皮质醇增多症，包括内源性或外源性。尽管外源性糖皮质激素的应用和酗酒是最常见的非创伤性原因之一，但多种创伤和非创伤因素导致了 AVN 的发病机制。由于内源性皮质醇增多症导致的 AVN 很少见，只有少数病例报告描述了这种并发症。目前尚无文献报道肾上腺手术后出现 AVN。在这里，我们介绍了一位年轻女性，她在因库欣综合征行肾上腺切除术 1 年后出现双侧髋关节骨坏死。
