Golden R N, Hsiao J K, Lane E, Ekstrom D, Rogers S, Hicks R, Potter W Z
University of North Carolina School of Medicine, Chapel Hill 27599.
Psychiatry Res. 1990 Jan;31(1):39-47. doi: 10.1016/0165-1781(90)90107-g.
The neuroendocrine responsivity to an acute serotonergic challenge with low-dose i.v. clomipramine was studied in seven drug-free depressed patients and seven age-matched healthy control subjects. The depressed patients had higher baseline prolactin concentrations than the healthy subjects, and their prolactin response to clomipramine, assessed as either the percent of baseline or the log-transformed concentration, was significantly different (delayed and blunted peak response) compared to healthy controls. The growth hormone response was exaggerated in the depressed patients, and there were also trends toward blunting in their cortisol and adrenocorticotropic hormone responses. These results are consistent with previous findings of altered neuroendocrine responses to a variety of putative serotonin agonists in depressed patients.
对7名未服用药物的抑郁症患者和7名年龄匹配的健康对照者进行了研究，以探讨静脉注射低剂量氯米帕明引发急性血清素能刺激时的神经内分泌反应性。抑郁症患者的基线催乳素浓度高于健康受试者，与健康对照组相比，其对氯米帕明的催乳素反应（以基线百分比或对数转换浓度评估）有显著差异（反应峰值延迟且减弱）。抑郁症患者的生长激素反应增强，其皮质醇和促肾上腺皮质激素反应也有减弱趋势。这些结果与之前关于抑郁症患者对多种假定血清素激动剂的神经内分泌反应改变的研究结果一致。
