2005-2007 年中国江门地区儿童诺如病毒胃肠炎的分子流行病学研究。

Molecular epidemiology of norovirus gastroenteritis in children in Jiangmen, China, 2005-2007.

机构信息

Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Tonghe Road, Guangzhou 510515, Guang Dong, People's Republic of China.

出版信息

Arch Virol. 2011 Sep;156(9):1641-6. doi: 10.1007/s00705-011-1010-3. Epub 2011 May 12.

DOI:10.1007/s00705-011-1010-3

PMID:21562879

Abstract

Human noroviruses (NoVs) are an important cause of epidemic acute gastroenteritis. Their role in sporadic cases, however, is less clear. In this study, we performed a two-year surveillance (September 2005 to August 2007) of NoV gastroenteritis in outpatient clinics in a southern city of China, Jiangmen City. NoVs were detected in 115 patients (115/881, 13.1%) with 30 (26.1%) co-infections with rotaviruses. Sequence analysis showed that all 115 NoVs belonged to genogroup II, with GII.4 being the most predominant (87.8%). NoV-associated infection can be seen year-around, with autumn and winter peaks. This study provides basic information on sporadic cases of major NoV gastroenteritis in children in different seasons, which is valuable for future disease control and prevention.

摘要

人类诺如病毒（NoVs）是引起流行性急性肠胃炎的一个重要原因。然而，它们在散发病例中的作用尚不明确。在这项研究中，我们对中国南方城市江门的门诊进行了为期两年的诺如病毒肠胃炎监测（2005 年 9 月至 2007 年 8 月）。在 881 例患者中，有 115 例（115/881，13.1%）检测到诺如病毒，其中 30 例（26.1%）与轮状病毒合并感染。序列分析显示，所有 115 株诺如病毒均属于基因 II 组，其中 GII.4 是最主要的基因型（87.8%）。诺如病毒感染全年可见，秋冬季为高峰。本研究为不同季节儿童散发性诺如病毒肠胃炎的主要病例提供了基础信息，对于今后的疾病控制和预防具有重要价值。