Xu Jin, Yang Yi, Sun Jiae, Ding Yunzhen
Pediatric Institute, Children's Hospital of Fudan University, Shanghai, China.
J Med Virol. 2009 Oct;81(10):1826-30. doi: 10.1002/jmv.21569.
Norovirus is one of the major causes of outbreaks and sporadic cases of acute gastroenteritis in young children worldwide. Obtaining local baseline information regarding this virus is important for developing and evaluating prevention strategies of norovirus transmission in children. The age, seasonal distribution and circulating genotypes of norovirus in Shanghai, China, between 2001 and 2005 were determined. Of 5411 stool specimens collected from children under 5 years of age who were hospitalized with acute gastroenteritis 3,975 were rotavirus-negative, indicating the presence of another causative agent. From these specimens, 484 were selected at random for genotyping, and 45 were norovirus-positive. Norovirus infection was detected in all age groups, but infants less than 6 months old showed the lowest prevalence (5.4%). Norovirus infections peaked from August to November. Among the 37 identified norovirus strains, 2 were GII-3, 2 were GII-7, and 33 were GII-4 genotypes. This study demonstrated the impact of norovirus infection causing acute gastroenteritis in hospitalized children and the importance of vaccination against norovirus diarrhea in Shanghai, China.
诺如病毒是全球范围内导致幼儿急性胃肠炎暴发和散发病例的主要原因之一。获取有关该病毒的当地基线信息对于制定和评估儿童诺如病毒传播的预防策略至关重要。我们确定了2001年至2005年间中国上海诺如病毒的年龄、季节分布和流行基因型。在因急性胃肠炎住院的5岁以下儿童采集的5411份粪便标本中，3975份轮状病毒检测呈阴性，表明存在其他病原体。从这些标本中随机选取484份进行基因分型，其中45份诺如病毒呈阳性。所有年龄组均检测到诺如病毒感染，但6个月以下婴儿的感染率最低（5.4%）。诺如病毒感染在8月至11月达到高峰。在鉴定出的37株诺如病毒菌株中，2株为GII-3型，2株为GII-7型，33株为GII-4基因型。本研究证明了诺如病毒感染对住院儿童急性胃肠炎的影响以及在中国上海接种诺如病毒腹泻疫苗的重要性。
