W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA.
J Mater Sci Mater Med. 2011 Jun;22(6):1511-9. doi: 10.1007/s10856-011-4332-5. Epub 2011 May 12.
The purpose of this first generation investigation is to evaluate the in vitro cytotoxicity, cell-materials interactions and tribological performance of Spinel and ALON® transparent ceramics for potential wear resistant load bearing implant applications. Besides their non-toxicity, the high surface energy of these ceramics significantly enhanced in vitro cell-materials interactions compared to bioinert commercially pure Ti as control. These transparent ceramics with high hardness in the range of 1334 and 1543 HV showed in vitro wear rate of the order of 10⁻⁶ mm³ Nm⁻¹ against Al₂O₃ ball at a normal load of 20 N.
本代研究的目的是评估尖晶石和 ALON®透明陶瓷的体外细胞毒性、细胞-材料相互作用和摩擦学性能，以评估其在潜在的耐磨承重植入物应用中的潜力。除了无毒之外，这些陶瓷的高表面能与生物惰性商业纯 Ti 相比，显著增强了体外细胞-材料相互作用。这些硬度在 1334 和 1543 HV 范围内的透明陶瓷在 20 N 的正常负载下对 Al₂O₃ 球的体外磨损率约为 10⁻⁶ mm³ Nm⁻¹。
