Department of Imaging Sciences and Rochester Center for Brain Imaging, University of Rochester, Rochester, New York, USA.
J Magn Reson Imaging. 2011 Mar;33(3):698-703. doi: 10.1002/jmri.22434.
To improve signal-to-noise ratio (SNR) of intermolecular double-quantum coherence (iDQC) MRS on a 3 Tesla (T) whole-body scanner.
A 32-channel phased array coil was used to acquire iDQC signal of a MRS phantom in the presence of large field inhomogeneity. The obtained individual spectra from the array elements were combined together in the time domain using a multichannel nonparametric singular value decomposition algorithm. The results were compared quantitatively with those acquired with a circularly polarized (CP) head coil.
The achieved gain in SNR ranges from 1.63 to 2.10 relative to the CP coil, mainly depending on the relative position between the surface of the phased array coil and the voxel of acquisition.
SNR enhancement of iDQC MRS in inhomogeneous fields on a 3T whole-body scanner is feasible with phased array coils. This can facilitate iDQC applications of high-resolution in vivo spectroscopy in the presence of field inhomogeneity for potential disease diagnosis in humans.
提高在 3 特斯拉（T）全身扫描仪上分子间双量子相干（iDQC）MRS 的信噪比（SNR）。
使用 32 通道相控阵线圈在存在较大磁场不均匀性的情况下获取 MRS 体模的 iDQC 信号。通过多通道非参数奇异值分解算法在时域中将来自阵列元件的各个频谱组合在一起。将结果与使用圆形极化（CP）头部线圈获得的结果进行定量比较。
与 CP 线圈相比，SNR 的增益范围为 1.63 至 2.10，主要取决于相控阵线圈表面与采集体素之间的相对位置。
使用相控阵线圈在 3T 全身扫描仪上不均匀场中增强 iDQC MRS 是可行的。这可以促进存在磁场不均匀性的情况下高分辨率体内光谱的 iDQC 应用，以便在人体中进行潜在疾病诊断。
