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Pyrophosphate-loaded hepatocytes show increased iron uptake from transferrin.

作者信息

Nilsen T, Romslo I

机构信息

Department of Clinical Chemistry, University of Trondheim, Norway.

出版信息

Scand J Clin Lab Invest. 1990 Feb;50(1):19-25. doi: 10.1080/00365519009091560.

DOI:10.1080/00365519009091560
PMID:2156334
Abstract

Exogenously added pyrophosphate was found associated with hepatocytes in suspension, particularly in the presence of calcium ions. The cell-associated pyrophosphate was recovered with the stroma fraction. Pyrophosphate thus bound did not affect cellular ATP, leakage of lactate dehydrogenase or trypan blue exclusion. Compared to control cells, pyrophosphate-loaded hepatocytes showed an approximately 70% increase in iron accumulation from transferrin. The excess iron was handled by the pyrophosphate-loaded cells as control cells. The relevance of pyrophosphate to hepatocyte iron uptake is discussed.

摘要

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