Nilsen T, Romslo I
Biochim Biophys Acta. 1984 Jul 27;766(1):233-9. doi: 10.1016/0005-2728(84)90236-6.
Rat liver mitochondria accumulate iron mobilized from transferrin by pyrophosphate. The capacity of the mitochondria to accumulate iron is higher than the capacity of pyrophosphate to mobilize iron from transferrin: with ferric-iron-pyrophosphate as iron donor, iron uptake and heme synthesis are about 10-times that at corresponding concentrations of iron-transferrin plus pyrophosphate. Uptake of iron from ferric-iron-pyrophosphate depends on a functionary respiratory chain and involves reductive cleavage of the ferric-iron-pyrophosphate complex. Apotransferrin inhibits uptake of iron from ferric-iron-pyrophosphate by competing with the mitochondria for iron. The results focus on pyrophosphate as a possible candidate for intracellular iron transport.
大鼠肝脏线粒体可积累由焦磷酸从转铁蛋白中动员出来的铁。线粒体积累铁的能力高于焦磷酸从转铁蛋白中动员铁的能力：以铁 - 焦磷酸作为铁供体时，铁摄取和血红素合成约为相应浓度的铁 - 转铁蛋白加焦磷酸时的10倍。从铁 - 焦磷酸摄取铁依赖于功能正常的呼吸链，且涉及铁 - 焦磷酸复合物的还原裂解。脱铁转铁蛋白通过与线粒体竞争铁来抑制从铁 - 焦磷酸摄取铁。这些结果聚焦于焦磷酸作为细胞内铁转运的一个可能候选物。
