Farboud A, Trinidade A, Shakeel M, Rajapaksa S, Hanif J
Royal Darwin Hospital, Darwin, Australia.
B-ENT. 2011;7(1):47-9.
To highlight a rare scenario where a delay in diagnosis caused unilateral blindness.
A 45-year-old Aboriginal woman with a history of non-Hodgkin's lymphoma presented with a severe left-sided headache, pyrexia and positive blood cultures. Following admission, the patient rapidly developed unilateral blindness, but did not inform her physician until 21 hours after onset. High-resolution CT scanning of the sinuses showed erosion of the bony covering of the optic nerve. Sinus surgery was performed.
Despite the discovery of pus under considerable pressure, and clearing the sphenoid sinus of pus and debris, vision was not restored, even at 2-month follow-up.
Two pathological processes are postulated here: that erosion of the bony optic canal allowed the optic nerve to be exposed, allowing the ensuing sinusitis to cause irreversible nerve ischemia, and immunosuppression meant the patient's immune response was inadequate to cope with the sinusitis, with devastating effects.
强调一种因诊断延迟导致单侧失明的罕见情况。
一名45岁有非霍奇金淋巴瘤病史的原住民女性,出现严重的左侧头痛、发热和血培养阳性。入院后,患者迅速出现单侧失明,但直到发病21小时后才告知医生。鼻窦高分辨率CT扫描显示视神经骨覆盖层侵蚀。进行了鼻窦手术。
尽管发现有大量脓液,且清除了蝶窦内的脓液和碎屑,但即使在2个月的随访中,视力也未恢复。
这里假设存在两个病理过程:视神经管骨质侵蚀使视神经暴露,继而鼻窦炎导致不可逆的神经缺血;免疫抑制意味着患者的免疫反应不足以应对鼻窦炎,从而产生了灾难性后果。