Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Curr Opin Cell Biol. 2011 Aug;23(4):427-34. doi: 10.1016/j.ceb.2011.04.009. Epub 2011 May 10.
Mitochondrial division has emerged as a key mechanism for this essential organelle to maintain its structural integrity, intracellular distribution, and functional competence. An evolutionarily conserved dynamin-related GTPase, Dnm1p/Drp1, interacts with other proteins to form the core machinery involved in mitochondrial division. We summarize recent progress in understanding how the division machinery assembles onto mitochondria and how mitochondrial division contributes to cellular physiology and human diseases.
线粒体分裂作为一种关键机制，可维持该细胞器的结构完整性、细胞内分布和功能能力。一种进化上保守的与 dynamin 相关的 GTP 酶，Dnm1p/Drp1，与其他蛋白质相互作用，形成参与线粒体分裂的核心机器。我们总结了近期在理解分裂机器如何组装到线粒体以及线粒体分裂如何促进细胞生理学和人类疾病方面的进展。
