Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany.
Int J Med Microbiol. 2011 Jun;301(5):423-30. doi: 10.1016/j.ijmm.2011.04.010. Epub 2011 May 11.
Infectious diseases caused by human pathogenic fungi represent a major and global health problem. Based on the limited efficacy of existing drugs and the increasing resistance to antifungal compounds, new strategies are urgently needed to fight such fungal infections. The medically important pathogen Candida albicans can exist as an opportunistic yeast, but can also cause severe diseases, septicaemia, and death. In order to establish new strategies to fight Candida infections and to interfere with survival of the pathogen, it is highly relevant to understand the molecular and immunology interactions between the pathogen C. albicans and the human host. This immune cross talk has moved into the focus of infectious disease research. In this review, we summarize the diverse and multiple levels of the immune cross talk between the fungal pathogen C. albicans and the human host. In particular, we define how one single fungal protein Pra1 (pH-regulated antigen 1) interferes and controls host immune attack at multiple levels and thus contributes to fungal immune escape. Candida Pra1 represents a promising candidate for immune interference.
由人体致病真菌引起的传染病是一个重大的全球性健康问题。鉴于现有药物疗效有限，以及抗真菌化合物的耐药性不断增加，迫切需要新的策略来对抗此类真菌感染。医学上重要的病原体白色念珠菌可以作为一种机会性酵母存在，但也会导致严重疾病、败血症和死亡。为了制定新的策略来对抗念珠菌感染并干扰病原体的存活，了解病原体白色念珠菌与人类宿主之间的分子和免疫学相互作用非常重要。这种免疫串扰已成为传染病研究的焦点。在这篇综述中，我们总结了真菌病原体白色念珠菌与人类宿主之间免疫串扰的多样性和多个层面。特别是，我们定义了单个真菌蛋白 Pra1（pH 调节抗原 1）如何在多个层面上干扰和控制宿主免疫攻击，从而有助于真菌的免疫逃逸。白色念珠菌 Pra1 是一种有前途的免疫干扰候选物。
