Institute for Interfacial Engineering, University of Stuttgart, Nobelstr. 12, 70569 Stuttgart, Germany.
Int J Med Microbiol. 2011 Jun;301(5):384-9. doi: 10.1016/j.ijmm.2011.04.004. Epub 2011 May 14.
Infectious diseases have long been regarded as losing their threat to mankind. However, in the recent decades infectious diseases have been regaining grounds and are back in the focus of research. This is also due to the fact that medical progress has enabled us to treat and cure a much higher fraction of severe diseases or trauma, resulting in a significant proportion of temporarily or constantly immune-suppressed patients. Infectious diseases result from the interplay between pathogenic microorganisms and the hosts they infect, especially their defense systems. Consequently, immune-suppressed patients are at high risk to succumb from opportunistic infections, like Candida infections. To study the balance between host and C. albicans with regard to the establishment of disease or asymptomatic, commensal colonisation, we developed host-pathogen interaction systems to study both the adaptation of C. albicans to different epithelia as well as to investigate the sensors of the innate immune system, the pattern recognition receptors. These host-pathogen interaction systems, as well as some of the results gained are described in this review.
传染病长期以来一直被认为对人类不再构成威胁。然而，近几十年来，传染病又重新抬头，成为研究的焦点。这也是由于医疗技术的进步使我们能够治疗和治愈更多严重疾病或创伤的患者，导致大量暂时或长期免疫抑制的患者出现。传染病是由致病微生物和受感染的宿主之间的相互作用引起的，特别是它们的防御系统。因此，免疫抑制的患者极易受到机会性感染的侵袭，如念珠菌感染。为了研究宿主和白色念珠菌之间的平衡，以了解疾病或无症状、共生定植的建立，我们开发了宿主-病原体相互作用系统，以研究白色念珠菌对不同上皮组织的适应以及调查先天免疫系统的传感器，即模式识别受体。本综述描述了这些宿主-病原体相互作用系统以及获得的一些结果。
