Center for Diabetes and Endocrine Research, Department of Physiology & Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA.
Curr Opin Pharmacol. 2011 Aug;11(4):332-7. doi: 10.1016/j.coph.2011.04.012. Epub 2011 May 11.
FK506-binding protein 51 (FKBP51) is gaining increased recognition for its essential roles in cell biology. Originally discovered as a component of steroid receptor complexes, it is now known to regulate a diverse set of transcription factors, enzymes and structural proteins. Its cellular properties suggest numerous possible functions for FKBP51 in physiology, and the best clue to its potential importance may be the following: FKBP51 is a glucocorticoid-induced negative regulator of the glucocorticoid receptor. Thus, FKBP51 is intricately involved in regulation of the most pleiotropic hormone known to biology. In contrast to glucocorticoid receptor, FKBP51 is a positive regulator of the androgen receptor, suggesting that it functions as a reciprocal modulator of glucocorticoid-mediated and androgen-mediated physiology. In this work, we evaluate this hypothesis by examining recent cellular and physiological evidence.
FK506 结合蛋白 51（FKBP51）因其在细胞生物学中的重要作用而受到越来越多的关注。它最初被发现是甾体激素受体复合物的一个组成部分，现在已知它可以调节多种转录因子、酶和结构蛋白。其细胞特性表明 FKBP51 在生理学中有许多可能的功能，而其潜在重要性的最好线索可能是：FKBP51 是糖皮质激素受体的糖皮质激素诱导的负调节剂。因此，FKBP51 深入参与了生物学中最具多效性的激素的调节。与糖皮质激素受体相反，FKBP51 是雄激素受体的正向调节剂，这表明它作为糖皮质激素介导和雄激素介导的生理学的反向调节剂发挥作用。在这项工作中，我们通过检查最近的细胞和生理证据来评估这一假设。
