暂停的 RNA 聚合酶 II 作为发育检查点。
Paused RNA polymerase II as a developmental checkpoint.
机构信息
Division of Genetics, Genomics, and Development, Department of Molecular and Cell Biology, Center for Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
出版信息
Cell. 2011 May 13;145(4):502-11. doi: 10.1016/j.cell.2011.04.021.
Abstract
The textbook view of gene activation is that the rate-limiting step is the interaction of RNA polymerase II (Pol II) with the gene's promoter. However, studies in a variety of systems, including human embryonic stem cells and the early Drosophila embryo, have begun to challenge this view. There is increasing evidence that differential gene expression often depends on the regulation of transcription elongation via the release of Pol II from the proximal promoter. I review the implications of this mechanism of gene activation with respect to the orderly unfolding of complex gene networks governing animal development.
摘要
教科书上对基因激活的观点认为，限速步骤是 RNA 聚合酶 II（Pol II）与基因启动子的相互作用。然而，包括人类胚胎干细胞和早期果蝇胚胎在内的各种系统的研究已经开始挑战这一观点。越来越多的证据表明，差异基因表达通常取决于通过 Pol II 从近端启动子释放来调节转录延伸。我回顾了这种基因激活机制对调控动物发育的复杂基因网络有序展开的影响。
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