Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, 1East, Room 3140, 10 Center Drive, Bethesda, MD 20892-1109, USA.
Endocrinol Metab Clin North Am. 2011 Jun;40(2):379-91, viii-ix. doi: 10.1016/j.ecl.2011.01.006.
Diagnosis of Cushing's syndrome involves a step-wise approach and establishing the cause can be challenging. Several pathogenic mechanisms have been proposed for glucocorticoid-induced hypertension, including a functional mineralocorticoid excess state, upregulation of the renin angiotensin system, and deleterious effects of cortisol on the vasculature. Surgical excision of the cause of excess glucocorticoids remains the optimal treatment. Antiglucocorticoid and antihypertensive agents and steroidogenesis inhibitors can be used as adjunctive treatment modalities in preparation for surgery and in cases where surgery is contraindicated or has not led to cure.
库欣综合征的诊断包括逐步的方法，确定病因可能具有挑战性。已经提出了几种糖皮质激素引起高血压的发病机制，包括功能性盐皮质激素过多状态、肾素-血管紧张素系统的上调以及皮质醇对血管的有害影响。切除过多糖皮质激素的病因仍然是最佳治疗方法。抗糖皮质激素和降压药物以及类固醇生成抑制剂可作为手术准备和手术禁忌或未治愈情况下的辅助治疗方法。
