Mikulski S
Int J Oncol. 1994 Jun;4(6):1257-63. doi: 10.3892/ijo.4.6.1257.
Abnormal regulation of cell proliferation and differentiation, both anti-apoptotic signals-driven functions on the one hand, and abnormal regulation of apoptosis or 'active' cell death on the other, determine the fate of the cell. Tumor cell growth and death are discussed in view of these mutually opposing biological activities. Specific molecular mechanisms, such as alternative splicing and protein homo- and hetero-dimerizations, as potential effectors of these opposing activities are reviewed. It is suggested that the efficacy of anti-cancer treatment could be augmented by using combinations of agents which act as pro-apoptotic and anti-anti-apoptotic signals. Since the latter may not themselves induce apoptosis, their effects might only be demonstrated as specific synergisms when such agents are combined with other drugs as specific treatment regimens against various types of cancer.
细胞增殖和分化的异常调节，一方面是抗凋亡信号驱动的功能，另一方面是凋亡或“程序性”细胞死亡的异常调节，决定了细胞的命运。鉴于这些相互对立的生物学活性，对肿瘤细胞的生长和死亡进行了讨论。本文综述了诸如可变剪接以及蛋白质的同源和异源二聚化等特定分子机制，它们可能是这些对立活性的潜在效应因子。有人提出，通过联合使用作为促凋亡信号和抗抗凋亡信号的药物，可以提高抗癌治疗的疗效。由于后者本身可能不会诱导凋亡，只有当这些药物与其他药物联合作为针对各种癌症的特定治疗方案时，其效果才可能表现为特定的协同作用。
