• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Butyrate-induced differentiation in leukemic myeloid cells - in-vitro and in-vivo studies.

作者信息

Rephaeli A, Nordenberg J, Aviram A, Rabizadeh E, Zimra Y, Nudelman A, Novogrodsky A, Shaklai M

机构信息

FELSENSTEIN MED RES CTR,IL-49100 TIKVA,ISRAEL. BAR ILAN UNIV,DEPT CHEM,IL-52900 RAMAT GAN,ISRAEL. HEMATOL INST,IL-49100 PETAH TIQWA,ISRAEL. TEL AVIV UNIV,BEILINSON MED CTR,ENDOCRINOL LAB,TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL.

出版信息

Int J Oncol. 1994 Jun;4(6):1387-91. doi: 10.3892/ijo.4.6.1387.

DOI:10.3892/ijo.4.6.1387
PMID:21567067
Abstract

A study of the effects of three differentiating agents, butyric acid, retinoic acid and cytosine arabinoside on proliferation and differentiation of primary cultures, obtained from sixteen patients with myelo-proliferative disorder was conducted. The results showed that BA was an effective inhibitor of cell proliferation and inducer of cytodifferentiation. An acute non-lymphoblastic leukemia patient was treated with sodium butyrate. A temporary increase in differentiation-associated parameters were noted. However, the effects of SB were short-lived. The lack of clinical response led to the development of a BA prodrug pivaloyloxymethylbutyrate (AN-9). This prodrug was more potent in vitro than BA in the induction of cytodifferentiation and inhibition of cell proliferation.

摘要

相似文献

1
Butyrate-induced differentiation in leukemic myeloid cells - in-vitro and in-vivo studies.
Int J Oncol. 1994 Jun;4(6):1387-91. doi: 10.3892/ijo.4.6.1387.
2
Tributyrin: a prodrug of butyric acid for potential clinical application in differentiation therapy.
Cancer Res. 1994 Jul 1;54(13):3494-9.
3
Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells.全反式维甲酸与丁酸及其前体药物联合使用可显著增强人急性早幼粒细胞白血病NB4细胞的分化。
Chin Med J (Engl). 1999 Apr;112(4):352-5.
4
Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.一种强效的20-表维生素D3类似物（KH 1060）与9-顺式视黄酸联合使用可不可逆地抑制HL-60白血病细胞的克隆生长，降低bcl-2表达，并诱导其凋亡。
Cancer Res. 1996 Aug 1;56(15):3570-6.
5
Induction of B-lymphocyte antigens on the chronic myeloid leukemic cell line K562 using sodium butyrate.使用丁酸钠在慢性髓性白血病细胞系K562上诱导B淋巴细胞抗原
Exp Hematol. 1987 May;15(4):406-13.
6
Study of differentiation of fresh human leukemic cells by low dose cytosine arabinoside (LD Ara-C) and 12-O-tetradecanoylphorbol-13-acetate (TPA).低剂量阿糖胞苷（LD Ara-C）和12-O-十四酰佛波醇-13-乙酸酯（TPA）对新鲜人白血病细胞分化的研究。
Neoplasma. 1989;36(5):589-97.
7
Potentiation of retinoic acid-induced differentiation of human acute promyelocytic leukemia NB4 cells by butyric acid, tributyrin, and hexamethylene bisacetamide.丁酸、三丁酸甘油酯和己二甲双乙酰胺对维甲酸诱导的人急性早幼粒细胞白血病NB4细胞分化的增强作用。
Oncol Res. 1998;10(2):75-84.
8
Accumulation of hypoxia-inducible factor-1 alpha protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid.缺氧诱导因子-1α蛋白的积累及其在全反式维甲酸诱导的髓系白血病细胞分化中的作用。
Haematologica. 2008 Oct;93(10):1480-7. doi: 10.3324/haematol.13096. Epub 2008 Aug 25.
9
Depletion of sodium butyrate from the culture medium of Friend erythroleukemia cells undergoing differentiation.从正在分化的弗氏红白血病细胞的培养基中去除丁酸钠。
Cancer Res. 1987 Jan 15;47(2):378-82.
10
Retinoic acid induction of CD38 antigen expression on normal and leukemic human myeloid cells: relationship with cell differentiation.维甲酸诱导正常人及白血病患者髓系细胞上CD38抗原的表达：与细胞分化的关系
Leuk Lymphoma. 2003 Apr;44(4):691-8. doi: 10.1080/1042819031000060564.

引用本文的文献

1
Milk fat components with potential anticancer activity-a review.具有潜在抗癌活性的乳脂肪成分综述。
Biosci Rep. 2017 Nov 15;37(6). doi: 10.1042/BSR20170705. Print 2017 Nov 22.
2
Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells.丁酸钠调节HT29人结肠腺癌细胞中与细胞周期相关的蛋白质。
Cell Prolif. 2000 Jun;33(3):139-46. doi: 10.1046/j.1365-2184.2000.00173.x.
3
Effect of the cytostatic butyric acid pro-drug, pivaloyloxymethyl butyrate, on the tumorigenicity of cancer cells.细胞生长抑制剂丁酸前体药物——丁酸特戊酯对癌细胞致瘤性的影响。
J Cancer Res Clin Oncol. 1997;123(5):267-71. doi: 10.1007/BF01208637.
4
Butyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells.丁酸和丁酸匹伐酯（AN-9，一种新型丁酸衍生物）可诱导HL-60细胞凋亡。
J Cancer Res Clin Oncol. 1997;123(3):152-60. doi: 10.1007/BF01214667.