Croker B P, Bourdon M, McConahey P J, Dixon F J
J Immunogenet. 1978 Dec;5(6):401-9. doi: 10.1111/j.1744-313x.1978.tb00669.x.
The levels of murine leukaemia virus (MuLV) proteins p30 and gp70, antinuclear antibody (ANA), anti-soluble nuclear protein, anti-single-stranded DNA, anti-double-stranded DNA and anti-histone antibodies were measured in B10.A and B10.A recombinant mice neonatally infected with MuLV-Scripps (Lerner et al., 1972). The incidence and latency of lymphoma and the incidence of glomerulonephritis were also determined. The mice studied could be divided into high-responder and low-responder groups. Most of the high ANA antibody could be attributed to anti-histone antibody. High response was associated with the H-2b haplotype and recombinant strains on the B10 background which were identical at the I-A subregion derived from the H-2b parental stock. In contrast, low ANA response was associated with the I-A subregion derived from the H-2k haplotype. In all groups of virus-inoculated animals, most animals developed serum elevations of p30 and gp70 and at least 72% of the inoculated animals developed lymphomas. High serum p30 levels correlated inversely with latency and directly with gp70 values. From 4 to 28% of the animals in each virus-inoculated group had histological evidence of glomerulonephritis, although no clear genetic basis could be ascribed to the incidence of glomerulonephritis, serum p30 or gp70 levels, or latency of lymphoma development.
在新生时感染了斯克里普斯鼠白血病病毒（MuLV）的B10.A和B10.A重组小鼠中，检测了鼠白血病病毒（MuLV）蛋白p30和gp70、抗核抗体（ANA）、抗可溶性核蛋白、抗单链DNA、抗双链DNA和抗组蛋白抗体的水平。还确定了淋巴瘤的发病率和潜伏期以及肾小球肾炎的发病率。所研究的小鼠可分为高反应组和低反应组。大多数高ANA抗体可归因于抗组蛋白抗体。高反应与H-2b单倍型以及B10背景上的重组菌株相关，这些重组菌株在源自H-2b亲本系的I-A亚区是相同的。相反，低ANA反应与源自H-2k单倍型的I-A亚区相关。在所有接种病毒的动物组中，大多数动物血清中的p30和gp70升高，并且至少72%的接种动物发生了淋巴瘤。血清p30高水平与潜伏期呈负相关，与gp70值呈正相关。每个接种病毒组中有4%至28%的动物有肾小球肾炎的组织学证据，尽管肾小球肾炎的发病率、血清p30或gp70水平或淋巴瘤发生的潜伏期没有明确的遗传基础。
