Leibovici Leonard, Paul Mical
Department of Medicine E, Beilinson-Tiqva.
Harefuah. 2010 Oct;149(10):661-4, 683.
The decline in the attraction and prestige of the clinician-scientist paradigm is due to the dissonance between clinical work and conducting research in basic science. Medicine entails alleviating distress and prolonging life. Thus, medical research deals directly with the questions: what ails our patients and what shortens their lives? How can it be prevented? How can we alleviate suffering and prolong life? Research designs that fit these questions are: researcher (or patient) initiated randomized controlled trials; systematic reviews and meta-analysis; high-quality observational studies that address risk factors, natural history of disease, side-effects, and efficiency of treatment; research in ethics; and qualitative research. The clinician-scientist should perform medical research. Investing in this paradigm wilt encourage young doctors to conduct research directly oriented to benefit their patients.
临床科学家模式的吸引力和威望下降,是由于临床工作与基础科学研究之间存在脱节。医学的目的是减轻痛苦和延长生命。因此,医学研究直接涉及以下问题:我们的患者患了什么病,是什么缩短了他们的生命?如何预防?我们如何减轻痛苦和延长生命?适合这些问题的研究设计包括:研究者(或患者)发起的随机对照试验;系统评价和荟萃分析;针对风险因素、疾病自然史、副作用和治疗效果的高质量观察性研究;伦理学研究;以及定性研究。临床科学家应该开展医学研究。对这种模式进行投入将鼓励年轻医生开展直接旨在造福患者的研究。