Martinović-Mitrović Sladjana, Dickov Aleksandra, Mitrović Dragan, Dickov Veselin
Srp Arh Celok Lek. 2011 Jan-Feb;139(1-2):69-75. doi: 10.2298/sarh1102069m.
Consequences of heroin abuse include organic damage of cerebral structures. The level of impairments is in a direct and positive relation with the length of heroin abuse.
The aim of this research was the evaluation of the reaction time with heroin addicts with different length of substance abuse.
90 examinees were divided into three groups with relation to the length of heroin abuse. Data collection included a questionnaire referring to socio-demographic and addictive characteristics. A specially designed programme was used for the evaluation of reaction time to audio/ visual signal.
In relation to the reaction time as overall model, the difference between examinees with different length of heroin abuse can be found on the marginal level of significance (F = 1.69; df = 12; p = 0.07). In visual modality, with the increase of length of heroin abuse leads to a significant prolongation of simple (the first visual sign: F = 3.29; df = 2; p = 0.04) and choice reaction time (the second visual sign: F = 4.97; df = 2; p = 0.00; the third visual sign: F = 3.08; df = 2; p = 0.05). Longer heroin consumption also leads to the prolongation of the simple (the first auditory task: F = 3.41; df = 2; p = 0.04) and the complex auditory reaction time (the second auditory task: F = 5.67; df = 2; p = 0.01; the third auditory task: F = 6.42; df = 2; p = 0.00).
Heroin abuse leads to the prolongation of both simple and choice reaction time in visual as well as auditory modality. The average daily dose of opiates was the most important predictor of the abovementioned cognitive dysfunction.
海洛因滥用的后果包括脑结构的器质性损害。损害程度与海洛因滥用时长呈直接正相关。
本研究旨在评估不同药物滥用时长的海洛因成瘾者的反应时间。
90名受试者根据海洛因滥用时长分为三组。数据收集包括一份关于社会人口统计学和成瘾特征的问卷。使用专门设计的程序评估对视听信号的反应时间。
就作为整体模型的反应时间而言，不同海洛因滥用时长的受试者之间的差异在边际显著水平上可以发现（F = 1.69；自由度 = 12；p = 0.07）。在视觉模式下，随着海洛因滥用时长的增加，简单反应时间（第一个视觉信号：F = 3.29；自由度 = 2；p = 0.04）和选择反应时间显著延长（第二个视觉信号：F = 4.97；自由度 = 2；p = 0.00；第三个视觉信号：F = 3.08；自由度 = 2；p = 0.05）。更长的海洛因使用时间也导致简单反应时间（第一个听觉任务：F = 3.41；自由度 = 2；p = 0.04）和复杂听觉反应时间延长（第二个听觉任务：F = 5.67；自由度 = 2；p = 0.01；第三个听觉任务：F = 6.42；自由度 = 2；p = 0.00）。
海洛因滥用导致视觉和听觉模式下简单反应时间和选择反应时间均延长。阿片类药物的日均剂量是上述认知功能障碍的最重要预测因素。
