Motlagh Farid, Ibrahim Fatimah, Rashid Rusdi, Seghatoleslam Tahereh, Habil Hussain
Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
Centre for Innovation in Medical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
J Neurosci Res. 2017 Aug;95(8):1633-1646. doi: 10.1002/jnr.23988. Epub 2016 Nov 8.
This study aims to introduce a new approach of a comprehensive paradigm to evaluate brain electrophysiological properties among addicts. Electroencephalographic spectral power as well as amplitudes and latencies of mismatch negativity (MMN), P300, and P600 components were evaluated among 19 male heroin addicts and 19 healthy nonsmoker subjects using a paradigm consisting of three subparadigms, namely (1) digit span Wechsler test, (2) auditory oddball, and (3) visual cue-reactivity oddball paradigms. Task 1 provided auditory P300 and P600 in association with working memory. Task 2 provided auditory P300 as well as small and large deviant MMN event-related potential (ERPs). Finally, task 3 provided visual cue-reactivity P300. Results show that beta power was higher among heroin addicts while delta, theta, and alpha powers were decreased compared with healthy subjects. ERP analysis confirmed the decline of brain-evoked potential amplitudes when compared with healthy subjects, thus indicating a broad neurobiological vulnerability of preattentive and attentional processing including attentional deficits and compromise of discrimination abilities. The prolonged latency of ERPs reflects poor cognitive capacity in the engagement of attention and memory resources. On the other hand, an increase of attention towards the heroin-related stimuli could be concluded from the increase of P300 in the cue-reactivity condition among heroin addicts. Findings suggest that applying this paradigm in addiction studies benefits comprehensive evaluation of neuroelectrophysiological activity among addicts, which can promote a better understanding of drugs' effects on the brain as well as define new neuroelectrophysiological characteristics of addiction properties. © 2016 Wiley Periodicals, Inc.
本研究旨在引入一种新的综合范式方法，以评估成瘾者的脑电生理特性。使用由三个子范式组成的范式，即（1）韦氏数字广度测试、（2）听觉oddball范式和（3）视觉线索反应oddball范式，对19名男性海洛因成瘾者和19名健康非吸烟者进行脑电图频谱功率以及失配负波（MMN）、P300和P600成分的振幅和潜伏期评估。任务1提供与工作记忆相关的听觉P300和P600。任务2提供听觉P300以及小偏差和大偏差MMN事件相关电位（ERP）。最后，任务3提供视觉线索反应P300。结果表明，与健康受试者相比，海洛因成瘾者的β功率较高，而δ、θ和α功率降低。ERP分析证实，与健康受试者相比，脑诱发电位振幅下降，从而表明包括注意力缺陷和辨别能力受损在内的前注意和注意加工存在广泛的神经生物学易损性。ERP潜伏期延长反映了在注意力和记忆资源参与方面认知能力较差。另一方面，从海洛因成瘾者线索反应条件下P300的增加可以得出，他们对与海洛因相关刺激的注意力增加。研究结果表明，在成瘾研究中应用这种范式有助于全面评估成瘾者的神经电生理活动，这可以促进更好地理解药物对大脑的影响，并确定成瘾特性的新神经电生理特征。©2016威利期刊公司
