Kosmehl H, Langbein L, Katenkamp D
Institute of Pathological Anatomy, Friedrich Schiller University, Jena, G.D.R.
J Pathol. 1990 Feb;160(2):135-40. doi: 10.1002/path.1711600207.
In murine sarcomas induced by 20-methylcholanthrene, histological features of malignant fibrous histiocytoma (MFH) as well as rhabdomyosarcoma were found in the same tumour both at light microscopy and at ultrastructural level. The areas showing rhabdomyomatous differentiation expressed vimentin, desmin, muscle-specific alpha-actinin, and sometimes myoglobin, but in the MFH areas only vimentin was expressed. A series of allografts in athymic mice, using tumour areas of both histological types, showed in every case a mixed pattern of tumour growth, whether the transplanted tissue was of MFH or rhabdomyosarcomatous type. This suggests that the MFH areas in the original experimental sarcomas were modulated disguised rhabdomyosarcomas. The significance of MFH-like areas in non-related soft tissue sarcomas is also discussed.
在由20-甲基胆蒽诱导的小鼠肉瘤中，在光学显微镜和超微结构水平上，同一肿瘤中均发现了恶性纤维组织细胞瘤（MFH）以及横纹肌肉瘤的组织学特征。显示横纹肌瘤样分化的区域表达波形蛋白、结蛋白、肌肉特异性α-肌动蛋白，有时还表达肌红蛋白，但在MFH区域仅表达波形蛋白。使用两种组织学类型的肿瘤区域在无胸腺小鼠中进行的一系列同种异体移植，无论移植组织是MFH型还是横纹肌肉瘤型，在每种情况下均显示出混合的肿瘤生长模式。这表明原始实验性肉瘤中的MFH区域是被调节伪装的横纹肌肉瘤。还讨论了非相关软组织肉瘤中MFH样区域的意义。
