Department of Microbiology and Immunology, The Cancer Research Institute, University of California, San Francisco, USA.
Adv Immunol. 2011;109:45-85. doi: 10.1016/B978-0-12-387664-5.00002-9.
Natural killer (NK) cells play an important role in host defense against tumors and viruses and other infectious diseases. NK cell development is regulated by mechanisms that are both shared with and separate from other hematopoietic cell lineages. Functionally, NK cells use activating and inhibitory receptors to recognize both healthy and altered cells such as transformed or infected cells. Upon activation, NK cells produce cytokines and cytotoxic granules using mechanisms similar to other hematopoietic cell lineages especially cytotoxic T cells. Here we review the transcription factors that control NK cell development and function. Although many of these transcription factors are shared with other hematopoietic cell lineages, they control unexpected and unique aspects of NK cell biology. We review the mechanisms and target genes by which these transcriptional regulators control NK cell development and functional activity.
自然杀伤 (NK) 细胞在宿主防御肿瘤、病毒和其他传染病方面发挥着重要作用。NK 细胞的发育受与其他造血细胞谱系共享和独立的机制调控。在功能上，NK 细胞使用激活和抑制受体来识别健康细胞和异常细胞，如转化或感染细胞。在激活后，NK 细胞使用与其他造血细胞谱系（尤其是细胞毒性 T 细胞）相似的机制产生细胞因子和细胞毒性颗粒。在这里，我们回顾了控制 NK 细胞发育和功能的转录因子。尽管其中许多转录因子与其他造血细胞谱系共享，但它们控制着 NK 细胞生物学的意想不到的独特方面。我们回顾了这些转录调节因子控制 NK 细胞发育和功能活性的机制和靶基因。
