Dermatology and Venereology Division, University Teaching Hospital, University of Zambia School of Medicine, Lusaka, Zambia.
Department of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, Zambia.
J Immunol Res. 2020 Nov 21;2020:8852221. doi: 10.1155/2020/8852221. eCollection 2020.
Kaposi's sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi's sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of the immune system likely play distinct roles in promoting or inhibiting KS development. This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.
卡波西肉瘤（KS）是一种血管增生性恶性肿瘤，其相关病因是卡波西肉瘤相关疱疹病毒（KSHV）。KS 是全球 HIV 感染者中最常见的恶性肿瘤，被认为是艾滋病定义性恶性肿瘤。不同形式的 KS 包括 HIV 相关 KS、医源性（免疫抑制相关）KS 和老年男性的经典 KS，表明免疫细胞失调是促进 KSHV 感染个体中 KS 发展的关键因素之一。因此，可以预期免疫系统的不同细胞类型可能在促进或抑制 KS 发展方面发挥不同的作用。本综述主要讨论了先天和适应性免疫系统细胞在 KSHV 感染和 KS 发病机制中的作用，包括这些细胞如何有助于控制 KSHV 感染和治疗 KS。
