Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Eur Psychiatry. 2012 Apr;27(3):223-8. doi: 10.1016/j.eurpsy.2011.02.004. Epub 2011 May 12.
Persistent impairment in cognitive function has been described in euthymic individuals with bipolar disorder. Collective work indicates that obesity is associated with reduced cognitive function in otherwise healthy individuals. This sub-group post-hoc analysis preliminarily explores and examines the association between overweight/obesity and cognitive function in euthymic individuals with bipolar disorder.
Euthymic adults with DSM-IV-TR-defined bipolar I or II disorder were enrolled. Subjects included in this post-hoc analysis (n=67) were divided into two groups (normal weight, body mass index [BMI] of 18.5-24.9 kg/m2; overweight/obese, BMI ≥ 25.0 kg/m2). Demographic and clinical information were obtained at screening. At baseline, study participants completed a comprehensive cognitive battery to assess premorbid IQ, verbal learning and memory, attention and psychomotor processing speed, executive function, general intellectual abilities, recollection and habit memory, as well as self-perceptions of cognitive failures.
BMI was negatively correlated with attention and psychomotor processing speed as measured by the Digit Symbol Substitution Test (P<0.01). Overweight and obese bipolar individuals had a significantly lower score on the verbal fluency test when compared to normal weight subjects (P<0.05). For all other measures of cognitive function, non-significant trends suggesting a negative association with BMI were observed, with the exception of measures of executive function (i.e., trail making test B) and recollection memory (i.e., process-dissociation task).
Notwithstanding the post-hoc methodology and relatively small sample size, the results of this study suggest a possible negative effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder. Taken together, these data provide the impetus for more rigorous evaluation of the mediational role of overweight/obesity (and other medical co-morbidity) on cognitive function in psychiatric populations.
在心境稳定的双相情感障碍患者中，认知功能持续受损已被描述。大量研究表明，肥胖与健康个体认知功能下降有关。本亚组事后分析初步探讨并检查了双相情感障碍患者中超重/肥胖与认知功能之间的关联。
纳入符合 DSM-IV-TR 定义的双相 I 或 II 型障碍的心境稳定成人。本事后分析纳入的受试者（n=67）分为两组（正常体重，体重指数[BMI]为 18.5-24.9kg/m2；超重/肥胖，BMI≥25.0kg/m2）。在筛选时获取人口统计学和临床信息。在基线时，研究参与者完成了全面的认知测试，以评估前驱期智商、言语学习和记忆、注意力和心理运动处理速度、执行功能、一般智力能力、回忆和习惯记忆，以及自我认知的认知失败。
BMI 与数字符号替代测试（Digit Symbol Substitution Test）测量的注意力和心理运动处理速度呈负相关（P<0.01）。与正常体重受试者相比，超重和肥胖的双相个体在言语流畅性测试中的得分明显较低（P<0.05）。对于认知功能的所有其他测量，观察到与 BMI 呈负相关的非显著趋势，除了执行功能（即追踪测试 B）和回忆记忆（即加工分离任务）的测量。
尽管采用了事后分析方法和相对较小的样本量，但本研究的结果表明，超重/肥胖可能对心境稳定的双相情感障碍患者的认知功能产生负面影响。综上所述，这些数据为更严格评估超重/肥胖（和其他医疗合并症）对精神科人群认知功能的中介作用提供了动力。
