Dalkner Nina, Bengesser Susanne A, Birner Armin, Fellendorf Frederike T, Fleischmann Eva, Großschädl Katja, Lenger Melanie, Maget Alexander, Platzer Martina, Queissner Robert, Schönthaler Elena, Tmava-Berisha Adelina, Reininghaus Eva Z
Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Front Neurosci. 2021 Aug 11;15:717824. doi: 10.3389/fnins.2021.717824. eCollection 2021.
Metabolic syndrome (MetS) is more prevalent in individuals with bipolar disorder and has a negative impact on cognition, in particular on executive function, which is already impaired in individuals with bipolar disorder compared to healthy controls. In a cross-sectional study, we compared 148 euthymic patients with bipolar disorder and 117 healthy controls in cognitive function depending on the diagnosis of MetS. A neuropsychological test battery was used including the Trail Making Test A/B, Stroop Color and Word Interference Test, the d2 Test of Attention Revised, and the California Verbal Learning Test. In addition, MetS variables as well as the defining variables waist circumference, serum triglyceride levels, high-density lipoprotein cholesterol levels, blood pressure, fasting glucose levels, and body mass index were compared between patients and controls. In addition, illness-related variables were associated with MetS in individuals with bipolar disorder. The prevalence of MetS in patients with bipolar disorder was higher than in controls (30.4 vs. 15.4%). Patients with bipolar disorder with MetS had impaired executive function compared to patients without MetS or healthy controls with and without MetS ( = 0.020). No MetS effects or interaction MetS × Group was found in attention/processing speed ( = 0.883) and verbal learning/memory ( = 0.373). Clinical variables (illness duration, suicidality, number of affective episodes, medication, age of onset, and history of psychosis) did not relate to MetS in bipolar disorder ( > 0.05). Bipolar disorder comorbid with MetS bears additional risk for impaired executive function. Executive function includes action planning, inhibition, and impulse control and could play a critical role in keeping long-term goals in mind associated with gaining and maintaining a healthy weight.
代谢综合征（MetS）在双相情感障碍患者中更为普遍，并且对认知有负面影响，尤其是对执行功能，与健康对照相比，双相情感障碍患者的执行功能已经受损。在一项横断面研究中，我们根据MetS的诊断比较了148名双相情感障碍心境正常的患者和117名健康对照的认知功能。使用了一套神经心理测试，包括连线测验A/B、斯特鲁普颜色和文字干扰测验、修订版d2注意力测验以及加利福尼亚言语学习测验。此外，还比较了患者和对照之间的MetS变量以及定义变量腰围、血清甘油三酯水平、高密度脂蛋白胆固醇水平、血压、空腹血糖水平和体重指数。此外，疾病相关变量与双相情感障碍患者的MetS相关。双相情感障碍患者中MetS的患病率高于对照组（30.4%对15.4%）。与没有MetS的双相情感障碍患者或有或没有MetS的健康对照相比，患有MetS的双相情感障碍患者的执行功能受损（P = 0.020）。在注意力/处理速度（P = 0.883）和言语学习/记忆（P = 0.373）方面未发现MetS效应或MetS×组的相互作用。临床变量（病程、自杀倾向、情感发作次数、用药情况、发病年龄和精神病病史）与双相情感障碍中的MetS无关（P>0.05）。双相情感障碍合并MetS会带来执行功能受损的额外风险。执行功能包括行动计划、抑制和冲动控制，在牢记与获得和维持健康体重相关的长期目标方面可能起着关键作用。
