Canada Research Chair in Mental Health Research, Department of Psychology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L3G1, Canada.
Biol Psychol. 2011 Jul;87(3):379-85. doi: 10.1016/j.biopsycho.2011.04.009. Epub 2011 May 13.
Although previous studies have shown that socially anxious individuals exhibit greater relative right frontal electroencephalogram (EEG) activity at rest, no studies have investigated whether improvements in symptoms as a result of treatment are associated with concomitant changes in resting brain activity. Regional EEG activity was measured at rest in 23 patients with social anxiety disorder (SAD) before and after cognitive behavioral therapy (CBT). Results indicated that patients shifted significantly from greater relative right to greater relative left resting frontal brain activity from pre- to posttreatment. Greater left frontal EEG activity at pretreatment predicted greater reduction in social anxiety from pre- to posttreatment and lower posttreatment social anxiety after accounting for pretreatment symptoms. These relations were specific to the frontal alpha EEG asymmetry metric. These preliminary findings suggest that resting frontal EEG asymmetry may be a predictor of symptom change and endstate functioning in SAD patients who undergo efficacious psychological treatment.
虽然先前的研究表明，社交焦虑个体在休息时表现出更大的相对右额脑电图（EEG）活动，但尚无研究调查治疗引起的症状改善是否与静息大脑活动的伴随变化相关。在认知行为治疗（CBT）之前和之后，对 23 名社交焦虑障碍（SAD）患者的静息状态进行了区域 EEG 活动测量。结果表明，患者从前治疗到后治疗时，从相对较大的右前额脑活动明显转变为相对较大的左前额脑活动。治疗前左额 EEG 活动越大，预测从治疗前到治疗后的社交焦虑减少越大，且治疗后社交焦虑较低，这些关系是针对前额 alpha EEG 不对称指标的。这些初步发现表明，在接受有效心理治疗的 SAD 患者中，静息额叶 EEG 不对称性可能是症状变化和终点功能的预测指标。
