Carreras Enric
Hospital Clínic, Barcelona, España. Director de REDMO-Fundación Josep Carreras contra la Leucemia, Barcelona, España.
Gastroenterol Hepatol. 2011 Nov;34(9):635-40. doi: 10.1016/j.gastrohep.2011.03.006. Epub 2011 May 14.
Hematopoietic stem cell transplantation is currently the main cause of hepatic veno-occlusive disease, which is the early complication of this procedure with the highest short-term morbidity and mortality. Given that mortality from severe hepatic veno-occlusive disease can be nearly 100%, the search for measures to prevent of treat this complication is essential. Several risk factors for this complication have been identified and the triggering event that leads to sinusoidal obstruction has been shown to be sinusoidal endothelial cell injury. The present review analyzes measures to avoid or modify the casual risk factors for this complication, as well as the pharmacological agents that can prevent or modify the initial endothelial dysfunction or the resulting sinusoidal occlusion.
造血干细胞移植是目前肝静脉闭塞病的主要病因，肝静脉闭塞病是该手术早期并发症中短期发病率和死亡率最高的。鉴于严重肝静脉闭塞病的死亡率可能接近100%，寻找预防和治疗这一并发症的措施至关重要。已经确定了该并发症的几个危险因素，并且导致窦性梗阻的触发事件已被证明是窦性内皮细胞损伤。本综述分析了避免或改变该并发症偶然危险因素的措施，以及可以预防或改变初始内皮功能障碍或由此产生的窦性闭塞的药物。
